5 Best Mattresses For Peripheral Neuropathy [2023]

If you have peripheral neuropathy, you know firsthand how this condition can affect your sleep quality. The numbness, weakness, and pain in your nerves can make it difficult to find a comfortable position at night. It can even worsen when you’re lying down or sleeping. This is why it’s so important to find a mattress that provides the necessary support and pressure relief for those with peripheral neuropathy.

There are several mattresses on the market that are designed specifically to cater to the needs of those with this condition.

These mattresses are made with high-density foam that contours to the body;reducing pressure points and helping to evenly distribute weight. They also have a medium-firm feel, which is essential for proper spinal alignment and support.

In this article, we will review the top mattresses for those with peripheral neuropathy.

We will provide tips on how to choose the best one for your needs. With the right mattress, you can improve your sleep quality and reduce the discomfort caused by neuropathy.


Best Mattresses For Peripheral Neuropathy

The best 5 mattresses for peripheral neuropathy are listed in the post below.

They aren’t really presented in any particular order since each is a little bit more customized to your sleeping position and body weight.

Saatva MattressEditor’s Pick

Best mattress for peripheral neuropathy


  • Offered in three levels of firmness: plush soft, firm, and luxury firm, so that it can accommodate people of all weight categories
  • Features an organic cotton cover that is breathable and helps regulate temperature
  • Uses carbon steel springs for added durability

Our top pick for the best mattress is the Saatva Classic. This flagship model from the Saatva brand consistently ranks among the best in the industry due to its exceptional quality.

The Saatva Classic offers a unique combination of memory foam and springs for maximum comfort, airflow, and cooling. Its sturdy, supportive base is made with 13 gauge backing coils and 884 hardened steel. Which are fired and triple tempered for long-lasting durability.

This mattress also features a double wire lumbar zone technology that provides targeted support for the midsection of the body and a memory foam layer for pressure relief in the lower back. The top layer features 416 individually wrapped 4.15 gauge comfort coils, which conform to the body’s contours and improve airflow.

In addition, the Saatva Classic has a dual perimeter edge support system to increase durability, and a clean, luxurious design reminiscent of traditional box spring mattresses.

Read More About Saatva Here


Nectar MattressBest Budget Mattress



  • Budget-friendly option, priced under $1,000
  • Five layers of premium materials for exceptional comfort and support
  • High-quality materials ensure optimal comfort, support, cooling, and suitability for all sleepers

The Nectar mattress is an affordable yet high-quality option for those with peripheral neuropathy. Its memory foam construction helps distribute weight evenly and reduce pressure points. Making it an excellent choice for minimizing body pain.

The Nectar mattress features multiple layers of foam for maximum comfort and support. The base layer is made of high-density foam, which is strong, durable, and stable, as well as highly breathable due to its specially designed foam channels.

The next layer is Adaptive Hi Core Memory Foam, which provides support and elasticity. This foam is of the highest quality and adapts to pressure points. The third layer is gel memory foam, which absorbs and distributes heat to keep you cool at night.

The top layer of the Nectar mattress is a gel quilted memory foam with a refreshing cover. This layer is soft and comfortable, helps regulate body temperature, and promotes air circulation. Overall, the Nectar mattress is a great choice for those who need a budget-friendly, high-quality mattress that is comfortable, supportive, and cooling.


Puffy Mattress

Puffy peripheral


  • Comprises three layers of foam for a restful, comfortable, and pressure-relieving sleep experience
  • Breathable design thanks to the use of gel-infused foams that can expand or contract based on temperature
  • ClimateComfort technology helps to maintain a neutral temperature for a comfortable sleep experience

Another great pick for those with peripheral neuropathy is the Puffy mattress, the first internet mattress from the brand. This 10-inch thick bed-in-a-box offers a simple yet comfortable memory foam style.  It is perfect for sensitive sleepers and those with neuropathies.

What sets the Puffy mattress apart is its technology-driven foams, which provide superior cooling and pressure-relieving benefits. It is a medium-firm universal mattress that is suitable for most people and features a three-layer design that is slightly flexible and adapts to the body.

The top layer is a 2-inch cooling foam that ensures breathability, followed by a 2-inch ClimateComfort layer that cradles the body and relieves pressure. The base layer is a 6-inch Firm Core support layer. This mattress is the result of four years of research and testing, and is known for its adaptive and breathable feel that is superior to traditional memory foam.

The Puffy mattress also comes with a removable and washable cover that is stain resistant. It uses ClimateControl technology, which allows users to sleep in a cool environment. Cooling gel is infused near the surface of the memory foam for extra coolness. Overall, the Puffy mattress is an excellent choice for those who need a comfortable, supportive, and cooling memory foam mattress.


Amerisleep AS3



  • Considered the most comfortable mattress for those with peripheral neuropathy due to its soft memory foam
  • Suitable for use on all types of bed bases, including adjustable bases
  • Gravity position is ideal for this condition
  • Features a Bio-Pur open-cell comfort layer that contours to the body and helps regulate temperature

Memory foam mattresses are a top choice for those with peripheral neuropathy due to their soft, cushioning nature, which makes the sleeper feel as though they are floating on air. Among memory foam mattresses, the multi-award-winning AS3 from Amerisleep stands out as a particularly exceptional option.

This mattress has received numerous accolades, including being named the Best Mattress in a Box, Best Memory Foam Mattress, Best Mattress, and Best Mattress by USA Today, Sleep Foundation, Healthline, and Mattress Clarity, respectively.

One unique feature of the AS3 is its use of rayon fiber made from natural cellulose as a fire sock material. In the event of a flame, this material is designed to melt and smother fires, making it a safer option compared to some other fire retardants.

In addition, the AS3 is Greenguard certified and has passed Indoor Air Quality certification for low chemical emissions, making it an excellent choice for those with allergies. The mattress also features a Bio-Pur Comfort layer made from plant-based materials with an open-cell construction that is ideal for body contouring and temperature regulation.





  • Micro air springs are placed just below the foam for enhanced breathability and airflow
  • Euro-pillow top infused with gel helps to counter the heat retention of memory foam for a cooler sleep experience
  • Individually wrapped pocketed coils provide added edge support

Upon first trying out this mattress, we were struck by its softness and medium-firm stability, which Winkbeds refer to as a “Luxury firm.”

This level of firmness makes it suitable for all types of sleepers and has earned it multiple awards in the industry for being the best innerspring mattress, best stomach sleeping mattress, and best back sleeping mattress. We also voted this hybrid mattress as one of the best options for side sleepers.

As soon as you lie down on the soft top layer of this mattress, you’ll experience a cloud-like softness that envelops you. At the same time, the responsive coils beneath the surface provide gentle support, making for a comfortable and supportive sleep experience.



How To Choose The Best Mattress For Peripheral Neuropathy

Having a health condition that impacts sleep can be a difficult and frustrating experience, as sleep is essential for our well-being.

Fortunately, there are bedding options available for a wide range of health issues, including mattresses designed specifically for spinal stenosis, sciatica, and hip bursitis, to name a few. For those with peripheral neuropathy, we have reviewed some of the best mattresses for this condition, which also happen to be suitable for those with herniated disc problems.

When choosing the best mattress for peripheral neuropathy, it is important to consider factors such as support and comfort, firmness, breathability, and durability.

Support and Comfort

Peripheral neuropathy sufferers can benefit from various types of mattresses that offer both support and comfort, such as memory foam, latex, hybrid, and innerspring options.

Memory foam is a popular choice for those with peripheral neuropathy as it is able to conform to the body’s shape and provide relief for pressure points, reducing strain on the spine and joints. Memory foam is also able to evenly distribute body weight and reacts to heat and tension for maximum relaxation.

Latex mattresses offer similar pain-relieving benefits to memory foam, but in a firmer form. It is important to choose an organic latex mattress over synthetic models, as synthetic versions are not as durable and can have an unpleasant smell.

Hybrid mattresses combine the benefits of both foam and spring mattresses, offering the cushioning comfort of foam and the breathability of springs. These mattresses are suitable for hot sleepers and can be used with adjustable bed bases.

Innerspring mattresses, while not as popular as they once were, can still be a comfortable and welcoming option. They feature an internal spring system, but often lack the foam layers that provide pressure relief and motion isolation. These mattresses may be suitable for those who value a very resilient bed, but for those seeking healthy sleeping positions and pain relief, a hybrid or all-foam mattress may be a better choice.


It is debated among experts and consumers whether soft or firm mattresses are best for individuals with peripheral neuropathy.

Some argue that soft memory foam or medium-firm mattresses are beneficial because they evenly distribute the weight of the sleeper, minimizing pressure on specific points.

On the other hand, others believe that firm mattresses are the way to go because they minimize the surface area of the body in contact with the mattress, potentially reducing discomfort.


A mattress that promotes good airflow and temperature regulation can contribute to a more comfortable sleep experience.

There are a few different types of mattresses that can offer these benefits. For example, open-cell foam construction and innerspring mattresses tend to be more breathable.

Additionally, natural, breathable cover materials such as cotton can also help to promote airflow. Memory foam mattresses that are infused with gel may also have cooling properties, as the gel can help to regulate body temperature.

In general, it’s important to consider the breathability and temperature regulation of a mattress when making a purchase to ensure a more restful sleep.

Mattress Durability

The lifespan of a mattress can vary depending on the materials it is made of, the reputation and experience of the manufacturer, and the care it receives.

Latex and innerspring mattresses tend to have a longer lifespan, lasting up to 20 years, while memory foam and hybrid models may only last for a few years.

It is worth noting that some mattress companies offer sleep trials, allowing consumers to try out a mattress in their own home for a certain period of time before committing to a purchase.

These trials can range from a few months to a full year, and can give shoppers the opportunity to determine if a mattress is the right fit for them.

It is always a good idea to research the warranty and sleep trial options available when shopping for a new mattress.


Sleep and Peripheral Neuropathy Video

This video by Dr. Gibson shows the correlation between peripheral neuropathy and sleep



How do you sleep with peripheral neuropathy?

For individuals with neuropathy, sleeping on your back is generally considered the best position. This position can help to distribute your body weight evenly, which can reduce pressure on the affected areas and alleviate pain. A memory foam mattress is a good option for this position because it can conform to the body and provide contoured support and cushioning. This can help to reduce pressure points and improve circulation, which can improve sleep quality and comfort.

Is a firm mattress suitable for neuropathy?

Firm mattresses are often recommended for individuals with neuropathy because they can reduce the body’s surface area, which can reduce pressure points and improve circulation. However, some people may find that firm mattresses are not ideal for comfort because the weight of the body can be too much on the points of contact with the bed. This can cause discomfort and pain, and may not be suitable for individuals with chronic pain or other health conditions.


Closing Thoughts

For individuals living with peripheral neuropathy, pain and numbness in the muscles and spine can be a constant challenge, often worsening at night and making it difficult to get a good night’s rest.

However, a suitable mattress can provide some relief and help improve sleep quality. Memory foam and firm mattresses such as latex or spring models may be particularly helpful for these individuals.

If you or someone you know has neuropathy, how have you been able to manage the condition when it comes to sleep, and what type of mattress do you find most comfortable?